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KMID : 0369819930230010055
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Jorunal of Korean Pharmaceutical Sciences
1993 Volume.23 No. 1 p.55 ~ p.59
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Evaluation of Physical Properties of Mucosal Adhesive Tablets ( II ) : Dissolution Rate
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뱍광신/Park KS
정비환/차봉진/권종원/Chung BH/Cha BJ/Kwon JW
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Abstract
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Dissolution of mucosal adhesive tablets prepared with two polymers using hydroxypropylcellulose-H (HPC) and carbopol 934 (CP) was tested. Adhesive tablets containing HPC/CP and brilliant blue FCF (BB) were prepared from direct compression. Three factors of polymer ratio (HPC:CP), BB content and compression force were chosen as important factors of preparation and factorial analysis for these factors was carried out. Eight kinds of formulations from different combinations of three factors were prepared and dissolution test in pH 6.8 phosphate buffer solution was performed. Dissolution rate was significantly affected by HPC:CP ratio and BB content, but was not affected by compression force.
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